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Page 1
The Emerging Roles of CIB1 in Cancer.
Wang X, Peng X, Zhang X, Xu H, Lu C, Liu L, Song J, Zhang Y. Wang X, et al. Cell Physiol Biochem. 2017;43(4):1413-1424. doi: 10.1159/000481873. Epub 2017 Oct 11. Cell Physiol Biochem. 2017. PMID: 29017172 Free article. Review.
The mechanism of CIB1 in human diseases is still not clear, although multiple functions of CIB1 are modulated by interacting with numerous interacting partners. ...These recent advances have significantly expanded our understanding of the knowledge of CIB1 an …
The mechanism of CIB1 in human diseases is still not clear, although multiple functions of CIB1 are modulated by interacting w …
CIB1 regulates endothelial cells and ischemia-induced pathological and adaptive angiogenesis.
Zayed MA, Yuan W, Leisner TM, Chalothorn D, McFadden AW, Schaller MD, Hartnett ME, Faber JE, Parise LV. Zayed MA, et al. Circ Res. 2007 Nov 26;101(11):1185-93. doi: 10.1161/CIRCRESAHA.107.157586. Epub 2007 Nov 1. Circ Res. 2007. PMID: 17975111
Consistent with these findings, tissues derived from CIB1-deficient (CIB1-/-) mice have reduced growth factor-induced microvessel sprouting in ex vivo organ cultures and in vivo Matrigel plugs. ...These data therefore reveal a critical role for CIB1 in ischem …
Consistent with these findings, tissues derived from CIB1-deficient (CIB1-/-) mice have reduced growth factor-induced microves …
Binding of CIB1 to the alphaIIb tail of alphaIIbbeta3 is required for FAK recruitment and activation in platelets.
Naik MU, Naik TU, Summer R, Naik UP. Naik MU, et al. PLoS One. 2017 May 24;12(5):e0176602. doi: 10.1371/journal.pone.0176602. eCollection 2017. PLoS One. 2017. PMID: 28542214 Free PMC article.
METHODS: We used alphaIIb cytoplasmic domain peptide and CIB1-function blocking antibody to inhibit interaction of CIB1 with alphaIIb subunit as well as Cib1-/- platelets to evaluate the consequence of CIB1 interaction with alphaIIb on outside-in signa …
METHODS: We used alphaIIb cytoplasmic domain peptide and CIB1-function blocking antibody to inhibit interaction of CIB1 with a …
CIB1 protects against MPTP-induced neurotoxicity through inhibiting ASK1.
Yoon KW, Yang HS, Kim YM, Kim Y, Kang S, Sun W, Naik UP, Parise LV, Choi EJ. Yoon KW, et al. Sci Rep. 2017 Sep 22;7(1):12178. doi: 10.1038/s41598-017-12379-3. Sci Rep. 2017. PMID: 28939911 Free PMC article.
Although CIB1 has been shown to interact with multiple proteins, its biological function in the brain remains unclear. ...Genetic deficiency of the CIB1 gene enhances MPTP-induced neurotoxicity in dopaminergic neurons in CIB1(-/-) mice. ...
Although CIB1 has been shown to interact with multiple proteins, its biological function in the brain remains unclear. ...Genetic def …
Expression of CIB1 correlates with colorectal liver metastases but not with peritoneal carcinomatosis.
Jacob S, Bösch F, Schoenberg MB, Pretzsch E, Lampert C, Haoyu R, Renz BW, Michl M, Kumbrink J, Kirchner T, Werner J, Angele MK, Neumann J. Jacob S, et al. BMC Cancer. 2021 Nov 18;21(1):1243. doi: 10.1186/s12885-021-08927-w. BMC Cancer. 2021. PMID: 34794407 Free PMC article.

Furthermore, immunohistochemical validation demonstrated that the mean CIB1 expression in HEP was 80% higher than in M0 (p < 0.001). CONCLUSION: Gene expression analysis revealed that CIB1 is significantly overexpressed in CRC leading to liver metastases compared

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Furthermore, immunohistochemical validation demonstrated that the mean CIB1 expression in HEP was 80% higher than in M0 (p < 0.001

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Role of calcium integrin-binding protein 1 in the mechanobiology of the liver endothelium.
Wang C, Felli E, Selicean S, Nulan Y, Lozano JJ, Guixé-Muntet S, Bosch J, Berzigotti A, Gracia-Sancho J. Wang C, et al. J Cell Physiol. 2024 Mar 7. doi: 10.1002/jcp.31198. Online ahead of print. J Cell Physiol. 2024. PMID: 38451745 Free article.
Following the modulation of CIB1 with siRNA, the transcriptome was scrutinized to understand downstream effects of CIB1 downregulation. CIB1 expression is increased in LSECs in human cirrhosis. In vitro, CIB1 emerges as an endothelial BMMF. ...
Following the modulation of CIB1 with siRNA, the transcriptome was scrutinized to understand downstream effects of CIB1 downre …
Calcium-induced dissociation of CIB1 from ASK1 regulates agonist-induced activation of the p38 MAPK pathway in platelets.
Patel P, Naik MU, Golla K, Shaik NF, Naik UP. Patel P, et al. Biochem J. 2019 Oct 15;476(19):2835-2850. doi: 10.1042/BCJ20190410. Biochem J. 2019. PMID: 31530712 Free PMC article.
Furthermore, genetic ablation of Cib1 in mice augments agonist-induced Ask1/p38 activation. Together our results suggest that in resting platelets ASK1 is bound to CIB1 at low Ca2+ concentrations. Agonist-induced platelet activation causes an increase in intracellul …
Furthermore, genetic ablation of Cib1 in mice augments agonist-induced Ask1/p38 activation. Together our results suggest that in rest …
Camouflage Nanoparticles Enable in Situ Bioluminescence-Driven Optogenetic Therapy of Retinoblastoma.
Ding J, Lu J, Zhang Q, Xu Y, Song B, Wu Y, Shi H, Chu B, Wang H, He Y. Ding J, et al. ACS Nano. 2023 Apr 25;17(8):7750-7764. doi: 10.1021/acsnano.3c00470. Epub 2023 Apr 6. ACS Nano. 2023. PMID: 37022677
In biomimetic vectors, the photoreceptor CRY2 and its interacting partner CIB1 plasmid are camouflaged with folic acid ligands and luciferase NanoLuc-modified macrophage membranes. ...Furthermore, unlike external blue light irradiation, which causes retinal damage and corn …
In biomimetic vectors, the photoreceptor CRY2 and its interacting partner CIB1 plasmid are camouflaged with folic acid ligands and lu …
Optogenetic control of epithelial-mesenchymal transition in cancer cells.
Zhou X, Wang J, Chen J, Qi Y, Di Nan, Jin L, Qian X, Wang X, Chen Q, Liu X, Xu Y. Zhou X, et al. Sci Rep. 2018 Sep 20;8(1):14098. doi: 10.1038/s41598-018-32539-3. Sci Rep. 2018. PMID: 30237527 Free PMC article.
Here, we applied optogenetic controlled PI3K module (named 'Opto-PI3K'), which based on CRY2 and the N-terminal of CIB1 (CIBN), to rapidly and reversibly control the endogenous PI3K activity in cancer cells with light. ...
Here, we applied optogenetic controlled PI3K module (named 'Opto-PI3K'), which based on CRY2 and the N-terminal of CIB1 (CIBN), to ra …
Transcriptomics of post-stroke angiogenesis in the aged brain.
Buga AM, Margaritescu C, Scholz CJ, Radu E, Zelenak C, Popa-Wagner A. Buga AM, et al. Front Aging Neurosci. 2014 Mar 18;6:44. doi: 10.3389/fnagi.2014.00044. eCollection 2014. Front Aging Neurosci. 2014. PMID: 24672479 Free PMC article.
We found that both young and old infarcted rats initiated vigorous angiogenesis. However, the young rats had a higher vascular density by day 14 post-stroke. "New-for-stroke" genes that were linked to the increased vasculature density in young animals included Angpt2, Angp …
We found that both young and old infarcted rats initiated vigorous angiogenesis. However, the young rats had a higher vascular densit …
15 results